A peptide ingredient that reduces the activity of inflammatory markers in skin cells. As a result, the sensation of itch and discomfort of heat is significantly reduced. It also helps to restore damaged tissue, helping to resurface and repair inflamed skin. Clinical data has shown that this ingredient reduced the stinging sensation by 32% after one week of treatment. An immediate soothing affect was obtained after one hour of application. Further, hydration of the skin increased by 34% after one week. Acetyl hexapeptide-49 further reduces skin dryness and scaling and improves softness and suppleness in sensitive skin.